Variables

Scenario 1: With Polatuzumab + Rituximab + Cyclophosphamide + Doxorubicin + Prednisone
2023 2024 2025 2026 2027
Autologous stem cell transplant
Salvage Therapy + R (intention to proceed to transplant)
Platinum-Based Salvage Therapy
Chemotherapy
Chemo + R (including Pola+BR)
Rituximab
Bridging treatment + CAR-T
Allogenic hematopoietic cell transplant
Other treatments (Placeholder)






Scenario 2: Without Polatuzumab + Rituximab + Cyclophosphamide + Doxorubicin + Prednisone
2023 2024 2025 2026 2027
Autologous stem cell transplant "Rituximab + Cyclophosphamide + Doxorubicin + Vincristine + Prednisone"
Salvage Therapy + R (intention to proceed to transplant)
Platinum-Based Salvage Therapy
Chemotherapy
Chemo + R (including Pola+BR)
Rituximab
Bridging treatment + CAR-T
Allogenic hematopoietic cell transplant
Other treatments (Placeholder)
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>References:

[1] Smith A, Crouch S, Howell D, Burton C, Patmore R, Roman E. Impact of age and socioeconomic status on treatment and survival from aggressive lymphoma: a UK population-based study of diffuse large B-cell lymphoma. Cancer Epidemiol. 2015;39(6):1103-1112. doi:10.1016/j.canep.2015.08.015

Budget Impact model (BIM) of Polatuzumab + Rituximab + CHP for the treatment of 1L DLBCL

Looks good!

Looks good!
Scenario 1: With Polatuzumab + Rituximab + Cyclophosphamide + Doxorubicin + Prednisone
2023 2024 2025 2026 2027
Polatuzumab +
Rituximab +
Cyclophosphamide +
Doxorubicin +
Prednisone
"Rituximab +
Cyclophosphamide +
Doxorubicin +
Vincristine +
Prednisone" 		60.0% 30.0% 10.0% 5.0% 5.0%
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